Natalie goes to the clinic where Cuddy turns the case over to House and his team, saying that Natalie's liver is failing. House notes Foreman's vacation and that Cuddy keeps coming to him. She says it isn't and walks out. As they return to the case, Taub find a Christmas present for House but House angrily throws it away even though it's a valuable antique medical text. He wonders if the other students pranked Natalie and slipped her something. Chase and Kutner talk to the students and they eventually admit they slipped her some mushrooms. The boy who supplied them, Simon, didn't think they were dangerous but Chase notes that they can be if not prepared properly.
(House Season Season: 5 Episode: 11)
Foreman is checking up on Thirteen, who asks him what happened with his patient Janice. He says she dropped out of the trials but didn't say why. He tells Thirteen that she's improving and as she goes, she leaves him a thank-you present for Christmas.
Kutner and Taub got the school to get the mushrooms and discuss what House is up to, and figure it's legitimate. They go through Natalie's locker and find a bottle of painkillers. Cuddy asks Natalie why she was taking so many painkillers. Cuddy admits she doesn't have any kids and Natalie says she's overweight and the other kids hate her. Cuddy tells her to forget them and then talks to their parents, who insist Natalie didn't take the pills. However, Mrs. Soellner admits that Natalie has changed in the last year and finally agrees to have Cuddy give them the treatment for an overdose of the painkillers.
Kutner and Taub go to Wilson and describe the present, and he recognizes it. He admits it came from Irene Adler, a patient in 2001, who House saved after a desperate effort… then admits he's lying to them and he recognizes that it's a present that he gave to House a year ago. They're called away when Natalie's heart problems and high blood pressure. Cuddy goes over the case with House and he points it out, but Taub admits they called her in because Foreman is busy. They go back to differential but Taub goes along with House's gag and suggests that Cuddy gave him the present, and he thinks she loves him. House refuses to discuss it but Taub plays along and tells House to tell Cuddy he loves her. House quickly figures out they're on to him, remembers that Natalie volunteers at a homeless shelter and orders Taub to do an anal swabbing at the shelter.
House confronts Wilson, who wonders why House didn't open his present. He also wonders why House gave himself an imaginary present and figures the holidays are hard for House because he can't have a meaningful relationship. House thinks Wilson is trying to goad him into being nice to his patients, but Wilson says he isn't and even if it was he wouldn't worry. House admits he needs to stop being a jerk… and steals Wilson's ice cream.
(House Season Season: 5 Episode: 11 s05e11)
Thirteen goes to see Janice and asks if she can help. Janice says that she told Foreman the injections were making her ill and he told her to get over it. She refuses to be Foreman's guinea pig.
Taub meets with House and tells him a worker at the soup kitchen had tuberculosis and the symptoms match with what Natalie has. House orders standard treatment and then goes into the clinic for duty. He starts acting sympathetically with the first patient, Whitney, and realizes she's pregnant. Whitney wasn't aware she was pregnant and House quickly loses his patience when she claims she's a virgin.
As Natalie undergoes treatment, she starts to spasm due to brain problems and Cuddy concludes it isn't TB. House is back to differential and Cuddy is there again, and he wonders why. Cuddy says she cares for Natalie and House wonders if she does so because of the baby she lost. Kutner suggests a mold allergy to the mushrooms and House orders a prick test and anti-fungals.
Thirteen talks to Foreman about Janice and brings up the nausea. She suggests Foreman apologize but when he refuses, she accuses him of acting like House. When Foreman stands by his decision, she says he is House.
Whitney arrives with her fiancé Geoff and Whitney insists she didn't have sex. Geoff demands a paternity test and Whitney agrees to it. Meanwhile, Kutner and Taub give Natalie her test and suggests she talk with them. She says she's okay and works on her homework, noting that Simon brought it. Kutner calls security to hold Simon and demands to know what he did. Taub pulls him off and suggests Kutner is projecting his personal issues from being bullied in high school. Simon says that they used to be friends but he stopped when people made fun of him. He says that Natalie used to drink a lot ad he bought her alcohol with a fake ID until Natalie got her own. Cuddy confronts Natalie and warns that they can't get her on the transplant list if she's alcoholic. Natalie says she hasn't drunk in six months and bought the bottles without opening them, so she could still talk with Simon. Cuddy wonders why she stopped buying alcohol and Natalie doesn't have an answer. Cuddy explains that she initially didn't want children because of her screwed up relationships, but she changed as she got older.
House meets with Anna, a woman with asthma, and tries to be nice again. Anna demonstrates how she uses her inhaler… by spraying it on the outside of her neck. Anna storms out a moment later and Cuddy arrives to explain she thinks Natalie either wants to die or the attention that comes with it. He proscribes benzos for the seizures which just happens to be the same treatment for alcoholism. House then goes to see Whitney and Geoff and sees something shocking in the paternity test. He tells them to stay and walks out.
Foreman asks his partner, Dr. Schmidt, about whether he should pursue the case with Janice. She notes that they can't view the patients as people, only numbers. Foreman explains that a friend of his has the disease and she says she doesn't want to know: they can't afford to care and the test is a double-blind. He's not sure if he can be that detached but Schmidt says that's why she chose him: because he worked for House and she figured Foreman understood that.
Natalie flat lines when her heart stops and Taub revives her. Meanwhile, House returns to Jeff and Whitney and says that she didn't cheat on Jeff. The baby only has Whitney's DNA: parthenogenesis in Whitney caused by a calcium spike lead to her pregnancy, even though there's never been a documented case. In seven months she'll have a miracle birth.
Back in differential, House starts to explain about Whitney but Cuddy tells her they need to put Natalie on a pacemaker. Alcoholism would cause a heart rate increase. There's a high alk phos rating, suggesting leukemia, and they take it to Wilson who confirms it's possible. House orders testing and Cuddy wonders why he doesn't want to treat her. House wonders why she's so concerned and leaves it up to her. Wilson warns that there's nothing they can do and even a double transplant won't save her. Cuddy orders the biopsy.
Foreman goes to visit Janice and says he can put her in a separate trial with a drug that won't cause nausea. He gives her the forms and leaves.
An increasingly panicked Cuddy goes to see House and wonders if they've overlooking something. He points out that patients die every day and she can't afford to get worked up about all them. As he goes through his desk he finds a present from Whitney. He tells Cuddy about the supposed parthenogenesis and she notes the testing machine was down. House explains he faked the whole thing and then tosses his present to Wilson and says he won by proving he was nice to a patient and she thanked him. Cuddy is surprised but Wilson admits he was trying to be nice. Cuddy realizes that the seizures and liver failure indicate eclampsia, meaning Natalie was pregnant and her fetus is dead.
Cuddy explains to Natalie and her parents that she has eclampsia, and you can get it up to a month after giving birth. Natalie quit drinking when she discovered she was pregnant, and concealed it. Natalie admits Simon is the father and he doesn't know about it. She was worried the other students would find out, but when it stopped breathing she left it at a house near the soup kitchen. Cuddy admits the damage to the heart and liver are permanent and there's nothing they can do. Natalie admits she just put her coat over the baby and left her.
Cuddy goes to the abandoned apartment where Natalie left her dead baby. She finds a squatter living there and he tells her to leave. A woman comes in holding a baby and Cuddy realizes the woman isn't the mother. Cuddy wants to get the baby for treatment and says the woman has to let her go. Cuddy returns to the hospital and brings the baby to Natalie. Natalie holds her child and Simon arrives, and Kutner tells him to go in.
Kutner goes to the hospital Christmas party, clearly upset, and tells the others about what happened and that Natalie only has a couple of days left. The daughter is being kept for observation and could end up with Simon. Kutner then goes to see a man, Jonathan, and apologizes for bullying him in high school.
House visits Cuddy as she watches over the baby. She explains that the grandparents are putting the baby up for adoption, and she'll adopt it. House wishes her a Merry Christmas and leaves.
Thirteen visits Foreman and admits she was wrong and he's not House. Foreman says he got Janice on the trials as a Christmas gift to her, and proved he wasn't House as a gift for himself. She suggests they go to the party but they embrace and kiss.
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